Preclinical peptides, oligonucleotides, silicones, degraders and conjugates — specified like a plan, delivered like a part. You define the target, the scale, and the difficulty; we build the module.
This is how you work with us: build a request like blocks. Pick a capability, a target, a scale, a difficulty tier — and watch the specification, literature precedent, and an indicative price and lead time assemble in real time. Stack several targets into a list and submit them together.
The whole program is built the way the request is — from modules. Make the molecule, prove what you made, and move it downstream when it advances. Step by step, type by type: priced per synthetic step, scoped by capability type and difficulty tier. Take one module on its own, or stack them.
Make the molecule. Nine capability lines, priced by the step and scoped by difficulty tier — a single target or a whole library.
Prove what you made. Purity, identity, and full characterization with a certificate of analysis — bolted onto any synthesis, or run on its own.
When it advances. Scale-up and a clean handoff into partner development and GMP manufacturing — the same molecule, one step further.
Take any module on its own — but a program is only whole when all three are in place.
Modular work has a quiet advantage: each module goes to the person who does it best. A silicone-systems specialist, a metal-catalysis chemist, a purification lead — matched to the part they own, not one generalist stretched across all of it. Best part, best hands.
Vinyl & crosslinker systems, cure chemistry, functional PDMS.
Pd / Ni cross-couplings, hydrogenation, C–H functionalization.
Ring-closure screening, stapling, the cyclizations others avoid.
Phosphorothioate, modified bases & sugars, conjugation handles.
PDC / POC, GalNAc, ADC linker-payload, click handles.
Prep-HPLC, chiral separation, difficult isolations.
Retrosynthesis, feasibility, starting-material sourcing.
Gram-to-preclinical scale, clean handoff to development.
Every route is a stack of synthetic steps. Each step gets a difficulty tier, and the tier sets its per-step rate. Your quote is the sum of the steps — so a long route of routine steps can cost less than a short route of hard ones.
Precedented transformation; conditions transfer directly. Fixed rate per step.
Selectivity or functional-group conflicts; needs a condition / ligand screen. Rate plus screening.
No precedent, or purification is the bottleneck. Milestone-based, quoted case by case.
steps × per-step rate (by tier) × scale → estimate. Try a live estimate in the configurator →
Each line is deep by design. We work at research and preclinical scale — the range where speed, judgement, and clean characterization matter more than plant capacity.
The catalog — nucleosides & nucleotides, oligonucleotides, protected nucleosides, and peptide APIs — from stock or made to order. Browse the full catalog →
The analysis module. Every deliverable ships with data — standard methods for this work, trimmed to what you actually run.
A few representative problems — including targets other suppliers had turned down. Illustrative placeholders; replace with your real projects.
A 14-residue head-to-tail macrocycle with two non-natural residues. We screened closure conditions and delivered on the second attempt.
A phosphorothioate sequence carrying a non-standard base and a terminal azide for downstream conjugation.
The client had a structure in mind but no way to make it. We designed a 4-step sequence, confirmed feasibility and starting-material availability, then ran it.
Have a target but no route? We can design it →
Not the biggest bench — the one you call for the targets that are hard to make and easy to get wrong.
We take the hard end of each line — macrocycles, modified oligos, difficult conjugates — the work most catalogs decline.
A shop can run the reaction. We tell you whether your step is routine or a development problem — before you commit.
Research and preclinical scale, where flexibility and turnaround matter more than plant capacity.
A clear interface for Western and Chinese partners, with export classification and dangerous-goods handling built into delivery.
Match the engagement to the program.
Defined target, defined scope, fixed quote. Best for one-off molecules and building blocks.
A chemist reserved for your program, billed by the month. Best for ongoing or multi-target work.
A batch of related analogs run together — one scope, shared method development, lower cost per compound.
From first message to material in hand — a short, predictable path.
Target, scale, and timeline — or a structure you drew. Attach sequences, structures, or specs.
We classify each step's difficulty, confirm feasibility, and send a quote with scope and timeline.
Scope, price, and timeline confirmed. NDA in place first if you need one.
We make it and characterize it. You get progress updates on longer routes.
Material plus its data package, shipped with export and DG handling. Support continues after.
The things people ask before the first project. Replace or extend with your own.
Milligram to kilogram. Our focus is the research and preclinical range; kilogram requests are quoted separately.
No. Everything here is research-use and preclinical, made non-GMP. If you need GMP production, tell us — we can point you to the right team.
By the step. Each synthetic step carries a difficulty tier that sets its rate; your quote is the sum of the steps, adjusted for scale. Development-stage steps and kilogram scale are quoted case by case.
Typically within one working day of receiving a defined target and scale.
Often, yes — the hard end of each line is where we focus. Send the structure and we'll give an honest read on feasibility.
We design the route and confirm feasibility before committing to synthesis. Share the structure and what you know about it.
We'll sign an NDA before you share sensitive structures. Your targets, sequences, and data remain yours.
You do. Any IP generated for your project — routes, methods, and results — belongs to the customer, as set out in your agreement. We don't retain rights to your molecules or data.
Yes, with export classification and dangerous-goods handling managed as part of delivery.
Send the module you built, or just describe what you need. We reply with a tier assessment and a quote — typically within one working day. Or email us directly at info@ashlar-chem.com.